Opioid Analgesic · Anesthetic
Sufentanil is an opioid agonist that primarily acts on the μ opioid receptor, showing strong agonistic activity. It also exhibits moderate agonistic activity at the δ opioid receptor and weaker activity at the κ opioid receptor. These receptors belong to the rhodopsin family of GPCRs.
[MHRA/CHM advice]. . Opioids: reminder of risk of potentially fatal respiratory
Acetaminophen-related hepatotoxicity, a significant cause for liver failure.
Many practitioners have moved away from opioid-acetaminophen combination analgesics to avoid the risk of excessive acetaminophen exposure.
Source: Harrison 22e · p98-99
Exaggerated CNS depression.
Source: KDT 7e · p401
Marked depression of respiration, cardiac contractility, and blood pressure.
Carefully monitor respiratory and cardiovascular functions when co-administering benzodiazepines with opioids due to increased risk of severe depression of vital signs.
Source: KDT 7e · p383
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased CNS depression, potentially leading to overdose symptoms.
Not explicitly stated
Source: KDT 7e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: DDInter
Drug interaction classified as: synergy
Source: DDInter
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung·Verified: 2026-05-10 · House clinical team