Drug reference
tabun
Organophosphate cholinesterase inhibitor; Chemical warfare agent · Chemical Warfare Agent
Organophosphate cholinesterase inhibitor; Chemical warfare agentChemical Warfare Agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Tabun, an organophosphate, is among the most potent synthetic toxic agents known. It inhibits acetylcholinesterase by forming a stable conjugate with the active center serine through phosphorylation, leading to prolonged enzyme inhibition.
Pharmacokinetics
Bioavailability
Volatile, rapidly penetrates into the CNS from pulmonary inhalation of vapor or aerosol.
Metabolism
As an organophosphate, it is hydrolyzed by plasma and liver esterases (carboxylesterases and paraoxonases).
Related guidelines
Other Organophosphate cholinesterase inhibitor; Chemical warfare agent drugs
Ask House about tabun
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team