Drug reference
vx
Organophosphate cholinesterase inhibitor; Chemical warfare agent · Chemical Warfare Agent
Organophosphate cholinesterase inhibitor; Chemical warfare agentChemical Warfare Agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
VX, an organophosphate, is among the most potent synthetic toxic agents known. It inhibits acetylcholinesterase by forming a stable conjugate with the active center serine through phosphorylation, leading to prolonged enzyme inhibition.
Pharmacokinetics
Bioavailability
Slower dermal absorption but highly toxic.
Metabolism
As an organophosphate, it is hydrolyzed by plasma and liver esterases (carboxylesterases and paraoxonases).
Related guidelines
Other Organophosphate cholinesterase inhibitor; Chemical warfare agent drugs
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10