Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Triclabendazole
Anthelmintic
Also known as EGATEN
Anthelmintic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AmiodaroneSevereDatabaseDDInter
- AmisulprideSevereDatabaseDDInter
- AnagrelideSevereDatabaseDDInter
- Arsenic TrioxideSevereDatabaseDDInter
Mechanism
The provided textbook excerpts mention triclabendazole as an effective treatment for Fasciola hepatica and Paragonimus westermani infections, specifying dosage regimens. However, these texts do not describe the specific molecular target, cellular pathway affected, or the detailed mechanism of action by which triclabendazole exerts its anthelmintic effects.
Indications
Paragonimus westermani infectionFasciola hepatica infectionFascioliasisParagonimiasisliver fluke infection caused by Fasciola hepatica
Dosing
- Adult
- For Fasciola hepatica: single oral dose of 10 mg/kg. For Paragonimus westermani: 10 mg/kg daily for 3 days.
Pharmacokinetics
Protein binding
>99%
Metabolism
Rapidly oxidized into two major metabolites, triclabendazole sulfoxide and triclabendazole sulfone; triclabendazole sulfoxide is the active metabolite.
Drug interactions
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bepridil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cabozantinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Chloroquine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cisapride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Citalopram
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Anthelmintic drugs
Ask House about Triclabendazole
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e, Katzung·Verified: 2026-05-10 · House clinical team