Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Valganciclovir
Antiviral · Antiviral for Cytomegalovirus
AntiviralAntiviral for CytomegalovirusATC J05AB11
CDSCO approvedATC J05AB11
EXCRETION
—
not curated
INTERACTIONS
11 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 11 →
- AdalimumabSevereDatabaseDDInter
- CertolizumabSevereDatabaseDDInter
- CidofovirSevereDatabaseDDInter
- CladribineSevereDatabaseDDInter
Mechanism
Valganciclovir is an ester of ganciclovir. Ganciclovir is related to aciclovir and is more active against cytomegalovirus (CMV).
Indications
Initial treatment and maintenance treatment of CMV retinitis in acquired immunodeficiency syndrome (AIDS) patientsPreventing CMV disease following solid organ transplantation from a cytomegalovirus-positive donorCMV retinitis (initial control and sustained suppression)suppression of human CMV infectionscytomegalovirus retinitislong-term therapy for CMV retinitis (replaces i.v. ganciclovir)
Dosing
- Adult
- For Cytomegalovirus retinitis (in AIDS patients): Initially 900 mg twice daily for 21 days, then maintenance 900 mg daily. The induction regimen may be repeated if retinitis progresses.
Pharmacokinetics
Bioavailability
~60% (oral, food increases by ~25%)
Protein binding
—
Metabolism
Hydrolyzed rapidly to ganciclovir
Excretion
—
Side effects
Serious
- retinal detachment
- macular edema
Drug interactions
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cidofovir
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Deferiprone
Severe
Database
Clinical effect not specified
Source: DDInter
Etanercept
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Golimumab
Severe
Database
Clinical effect not specified
Source: DDInter
Infliximab
Severe
Database
Clinical effect not specified
Source: DDInter
Inotersen
Severe
Database
Clinical effect not specified
Source: DDInter
Zidovudine
Severe
Database
.
Source: DDInter
1 additional low-confidence interaction hidden — those rows lack a documented mechanism or management plan in our sources.
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Other Antiviral drugs
Ask House about Valganciclovir
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e, Katzung·Verified: 2026-05-10 · House clinical team