Drug reference

Abacavir + Lamivudine + Zidovudine

Antiretroviral · HIV Antiretroviral

Also known as Trizivir

AntiretroviralHIV Antiretroviral

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Trizivir is a fixed-dose combination containing abacavir, lamivudine, and zidovudine, all of which are nucleoside reverse transcriptase inhibitors (NRTIs). These agents act by interfering with the viral enzyme reverse transcriptase, thereby inhibiting the synthesis of viral DNA and preventing HIV replication.

Indications

HIV infection (use only if patient is stabilised for 6–8 weeks on the individual components in the same proportions)

Dosing

Adult: 1 tablet (Abacavir 300mg, Lamivudine 150mg, Zidovudine 300mg) by mouth twice daily.
Renal adjustment: Avoid if eGFR less than 50 mL/minute/1.73 m2.