Acalabrutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
Amprenavir
Antiretroviral
Antiretroviral
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
Toxicity in animal studies; manufacturer advises use only if potential benefit outweighs risk.
FDA category + note
Top interactionssee all 12 →
- AcalabrutinibSevereDatabaseDDInter
- AlfentanilSevereDatabaseDDInter
- AlfuzosinSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
Mechanism
Amprenavir is a protease inhibitor, working to prevent the replication of HIV. As a prodrug, fosamprenavir is converted to amprenavir, which then inhibits HIV proteases. These enzymes are crucial for cleaving viral gag and gag-pol polyproteins into functional proteins, a step necessary for the assembly of new, infectious virions.
Indications
HIV infection in combination with other antiretroviral drugs
Dosing
- Adult
- low-dose ritonavir (r). They boost the concentrations of other antiretrovirals metabolised by CYP3A4, but have no antiretroviral activity themselves. ANTIVIRALS › HIV-FUSION INHIBITORS Enfuvirtide l DRUG ACTION 14-Jul-2018 Enfuvirtide inhibits the fusion of HIV to the host cell.…
Side effects
Common
Oral paraesthesiaRash
Serious
- Severe rash with systemic or allergic symptoms or mucosal involvement
Pregnancy & lactation
Pregnancy
Toxicity in animal studies; manufacturer advises use only if potential benefit outweighs risk.
Drug interactions
Alfentanil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Alfuzosin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Artemether
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Astemizole
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atorvastatin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Avanafil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Avapritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Axitinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benznidazole
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Other Antiretroviral drugs
Ask House about Amprenavir
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Sources: BNF·Verified: 2026-05-13 · House clinical team