Rifampin
Severe
Textbook
Will reduce doravirine concentrations, potentially leading to loss of efficacy.
Should not be given with rifampin.
Source: G&G 14e · p1245-1266
Drug reference
Doravirine
Antiretroviral · Antiviral
Also known as DOR
AntiretroviralAntiviral
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- RifampinSevereTextbookG&G 14e · p1245-1266
- St John S WortSevereTextbookG&G 14e · p1245-1266
- ApalutamideSevereDatabaseDDInter
- BosentanSevereDatabaseDDInter
Mechanism
Doravirine is a non-nucleoside reverse transcriptase inhibitor. It works by inhibiting the activity of HIV-1 reverse transcriptase, an enzyme crucial for viral replication. This action prevents the virus from converting its RNA into DNA, thereby blocking viral replication.
Indications
HIV infectionAIDSHIV-1 infection in treatment-naïve adults
Dosing
- Adult
- 100 mg qd
Pharmacokinetics
Half-life
15
Bioavailability
64%
Protein binding
76%
Metabolism
CYP3A4, 3A5
Excretion
6% (renal, unchanged)
Side effects
Common
HeadacheNauseaDiarrheaRashIncreased liver enzymes
Drug interactions
St John S Wort
Severe
Textbook
Will reduce doravirine concentrations, potentially leading to loss of efficacy.
Should not be given with St. John's wort.
Source: G&G 14e · p1245-1266
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bosentan
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Carbamazepine
Severe
Database
Will reduce doravirine concentrations, potentially leading to loss of efficacy.
Should not be given with carbamazepine.
Source: DDInter
Cenobamate
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Dabrafenib
Severe
Database
Clinical effect not specified
Source: DDInter
Dexamethasone
Severe
Database
Clinical effect not specified
Source: DDInter
Efavirenz
Severe
Database
Clinical effect not specified
Source: DDInter
Enzalutamide
Severe
Database
Clinical effect not specified
Source: DDInter
Eslicarbazepine
Severe
Database
Clinical effect not specified
Source: DDInter
Etravirine
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Antiretroviral drugs
Ask House about Doravirine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team