Articaine

Articaine is an amide-type local anaesthetic that works by blocking nerve impulse conduction. It inhibits the influx of sodium ions through voltage-gated sodium channels in neuronal membranes, thereby preventing the generation and propagation of action potentials. The addition of a vasoconstrictor like adrenaline diminishes local blood flow, slowing its absorption and prolonging the anaesthetic effect.

Adult

Consult expert dental sources. To avoid excessive dosage in obese patients, dose should be calculated on the basis of ideal body-weight.

Renal adjustment

Manufacturers advise use with caution in severe impairment.

Hepatic adjustment

Manufacturer advises caution (increased risk of toxicity in severe impairment).

• Injection into infected tissues
• Injection into inflamed tissues
• Preparations containing preservatives should not be used for caudal, epidural, or spinal block
• Severe hypertension (if combined with adrenaline/epinephrine)
• Unstable cardiac rhythm (if combined with adrenaline/epinephrine)