Drug reference

Benzocaine

Local Anesthetic

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

2 major

SEVERE in our sources

PREGNANCY

g Bulk forming laxatives are not absorbed, and are

FDA category + note

Top interactions

Nitrous AcidSevereDatabaseDDInter
PrilocaineSevereDatabaseDDInter

Mechanism

Local anesthetics act at the cell membrane to prevent the generation and the conduction of nerve impulses. They block conduction by decreasing or preventing the large transient increase in the permeability of excitable membranes to Na+ that normally is produced by a slight depolarization of the membrane. This action is due to their direct interaction with voltage-gated Na+ channels, increasing the threshold for electrical excitability and declining the rate of rise of the action potential.

Indications

Local anesthesiaManagement of haemorrhoidsTopical preparations for wounds and ulcerated surfaces (sustained anesthetic action)StomatitisSore throatWoundsUlcerated surfacesAnorectal lesions (suppository)

Dosing

Adult: chronic anal ﬁssure in adults but is generally reserved for those who do not respond to drug treatment. h 9.2 Haemorrhoids Haemorrhoids 01-Dec-2016 Topical preparations containing local anaesthetics (lidocaine, benzocaine, cinchocaine and pramocaine) should only be used for a few days as they may cause sensitisation of the anal skin.…