Drug reference

Lidocaine and Prilocaine

Local Anesthetic · Anaesthesia

Also known as EMLA, Denela, Nulbia, Eutectic Mixture of Local Anesthetics

Local AnestheticAnaesthesia

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Lidocaine and prilocaine combine to form a eutectic mixture that permits anesthetic penetration of the keratinized layer of skin. This formulation produces localized numbness by blocking nerve impulse conduction.

Indications

Anesthesia prior to venipunctureSkin graft harvestingInfiltration of anesthetics into genitaliaAnesthetize the skin prior to intravenous catheter placement in pediatrics

Dosing

Adult: Apply a thick layer under an occlusive dressing 1 –5 hours before the procedure (2 –5 hours before procedures on large areas e.g. split skin grafting).
Pediatric: For children with atopic dermatitis, a shorter application time of 15 –30 minutes under an occlusive dressing is recommended (30 minutes before removal of mollusca).