Drug reference

Dibucaine

Local Anesthetic

Also known as Nupercainal, Cinchocaine

Local Anesthetic

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

2 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactions

Nitrous AcidSevereDatabaseDDInter
PrilocaineSevereDatabaseDDInter

Mechanism

Dibucaine acts at the cell membrane to prevent the generation and the conduction of nerve impulses. It blocks nerve impulse conduction by directly interacting with voltage-gated Na+ channels, decreasing or preventing the transient increase in Na+ permeability that occurs with membrane depolarization. This action increases the threshold for electrical excitability and slows impulse conduction, ultimately leading to a failure of nerve propagation.

Indications

Topical anesthesiaSurface anesthesiaOver-the-counter ointment for cutaneous useSurface anaesthetic on less delicate mucous membranes (anal canal)

Dosing

Adult: Intravenous lipid emulsion for overdose Intralipid Levobupivacaine Chirocaine, others Lidocaine Generic, Xylocaine Lidocaine and hydrocortisone (patch) Generic Lidocaine and bupivacaine mixture Duocaine Lidocaine and prilocaine eutectic mixture (topical) EMLA cream Mepivacaine Generic, Carbocaine Pramoxine (topical) Generic, Tronothane Prilocaine Citanest Procaine Generic, Novocain Proparacaine (o…