Drug reference

Benzathine benzylpenicillin

Penicillin · Antibiotic

Also known as Benzathine penicillin G

PenicillinAntibiotic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Benzathine benzylpenicillin, a beta-lactam antibiotic, exerts its bactericidal effect by interfering with bacterial cell wall synthesis. It irreversibly binds to and inactivates penicillin-binding proteins (PBPs), which are transpeptidases essential for cross-linking peptidoglycan strands in the bacterial cell wall. This inhibition prevents the formation of a stable cell wall, leading to increased osmotic pressure, cell lysis, and ultimately bacterial death.

Indications

ErysipelasYawsPintaSyphilis [primary and secondary stage]Syphilis [late-stage (latent seropositive)]Prophylaxis of rheumatic fever [without cardiac involvement]Prophylaxis of poststreptococcal glomerulonephritis [without cardiac involvement]Prophylaxis of erysipelas [without cardiac involvement]Prophylaxis of rheumatic fever [transient cardiac involvement]Prophylaxis of poststreptococcal glomerulonephritis [transient cardiac involvement]Prophylaxis of erysipelas [transient cardiac involvement]

Dosing

Adult: Erysipelas | Yaws | Pinta: 1.2 million units as a single deep intramuscular injection in the outer quadrant of the gluteus maximus or Hochstetter’s ventrogluteal field.…