Cloxacillin

Cloxacillin is an isoxazolyl penicillin (penicillinase-resistant penicillin) that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) and blocking transpeptidation of peptidoglycan. The bulky isoxazolyl side chain at the 6-position of the beta-lactam ring provides steric hindrance that prevents access by staphylococcal penicillinases (beta-lactamases), conferring activity against methicillin-susceptible Staphylococcus aureus (MSSA). Its narrow spectrum is restricted primarily to gram-positive cocci.

Adult

is ~0.5 unit/mL (0.3 μg/mL) after an oral dose of 400,000 units. (~250 mg) in an adult. Ingestion of food may interfere with enteric. 500 mg is nearly 3 μg/mL. Once absorbed, penicillin V is distributed in the body and excreted by the kidney in a manner similar to