Sulfasalazine
Contraindicated
Textbook
Exacerbation of inflammatory bowel disease (IBD).
Avoid combining sulfasalazine with traditional NSAIDs.
Source: G&G 14e · p1112
Drug reference
Capsaicin
NSAID · Analgesic
Also known as AXSAIN, QUTENZA, ZACIN
NSAIDAnalgesic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- SulfasalazineContraindicatedTextbookG&G 14e · p1112
- AminoglycosideSevereTextbookKDT 7e · p746
- AminoglycosidesSevereTextbookKDT 7e
- AnticoagulantsSevereTextbookKDT 7e
Mechanism
Capsaicin interacts with and activates transient receptor potential vanilloid 1 (TRPV1) channels, also known as vanilloid receptors, which are cation-permeable channels. This activation is responsible for its analgesic effects. Prolonged exposure leads to desensitization of TRPV1-expressing nociceptors, thereby reducing pain transmission.
Indications
Post-herpetic neuralgiaPeripheral neuropathic painPainful diabetic neuropathy (under expert supervision)Symptomatic relief in osteoarthritisLocalised neuropathic pain (off-label)pain reliefpostherpetic neuralgiaIncluded in counterirritant preparationsRelief of post-herpetic neuralgia on local application
Dosing
- Adult
- For localised neuropathic pain (0.075% cream): Apply to the skin 3–4 times a day, sparingly, not more often than every 4 hours. For post-herpetic neuralgia (0.075% cream): Apply to the skin 3–4 times a day, sparingly, after lesions have healed, not more often than every 4 hours.…
Side effects
Common
Intense burning sensation (during initial treatment)
Drug interactions
Aminoglycoside
Severe
Textbook
Increased risk of nephrotoxicity.
Avoid concurrent use.
Source: KDT 7e · p746
Aminoglycosides
Severe
Textbook
Increased aminoglycoside levels and potential toxicity.
Monitor aminoglycoside levels and renal function; adjust dosage as needed.
Source: KDT 7e
Anticoagulants
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider alternative analgesics or gastroprotective agents.
Source: KDT 7e
Ciprofloxacin
Severe
Textbook
Enhanced CNS toxicity, seizures reported.
Source: KDT 7e
Citalopram
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Clopidogrel
Severe
Textbook
Increased bleeding risk.
Exercise extra caution and monitor for signs of bleeding.
Source: G&G 14e
Corticosteroids
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents.
Source: KDT 7e
Cyclosporine
Severe
Textbook
Increased nephrotoxicity.
Avoid concomitant use or monitor renal function closely.
Source: KDT 7e
Dapoxetine
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Enalaprilat
Severe
Textbook
Reduced effectiveness of ACE inhibitors. Marked hyperkalemia, potentially leading to cardiac arrhythmia.
Use with caution, especially in the elderly and in patients with hypertension, diabetes mellitus, or ischemic heart disease.
Source: G&G 14e · p836
Escitalopram
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Related guidelines
Other NSAID drugs
Ask House about Capsaicin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-13 · House clinical team