Drug reference

Choline salicylate

NSAID · Topical analgesic, Oral mucosa treatment

NSAIDTopical analgesic, Oral mucosa treatment

CDSCO approvedOTC

EXCRETION

—

not curated

INTERACTIONS

12 major

incl. contraindicated

PREGNANCY

—

not curated

Top interactionssee all 12 →

SulfasalazineContraindicatedTextbookG&G 14e · p1112
AminoglycosideSevereTextbookKDT 7e · p746
AminoglycosidesSevereTextbookKDT 7e
AnticoagulantsSevereTextbookKDT 7e

Mechanism

Choline salicylate is a derivative of salicylic acid. It possesses analgesic action, providing relief for mild oral and perioral lesions.

Indications

Relief for recurrent aphthaeMild oral and perioral lesions

Dosing

Adult: Apply 0.5 inch with gentle massage, not more often than every 3 hours
Pediatric: Child 16–17 years: Apply 0.5 inch with gentle massage, not more often than every 3 hours. Contraindicated for children under 16 years.

Contraindications

Children under 16 years (due to theoretical risk of Reye's syndrome with salicylate salts)

Side effects

Common

Irritation of mucosa (with excessive application or confinement under a denture)Ulceration (with excessive application or confinement under a denture)

Serious

Bronchospasm
Salicylate poisoning (with frequent application, especially in children)

Drug interactions

Sulfasalazine

Contraindicated

Textbook

Exacerbation of inflammatory bowel disease (IBD).

Avoid combining sulfasalazine with traditional NSAIDs.

Source: G&G 14e · p1112

Aminoglycoside

Severe

Textbook

Increased risk of nephrotoxicity.

Avoid concurrent use.

Source: KDT 7e · p746

Aminoglycosides

Severe

Textbook

Increased aminoglycoside levels and potential toxicity.

Monitor aminoglycoside levels and renal function; adjust dosage as needed.

Source: KDT 7e

Anticoagulants

Severe

Textbook

Increased risk of gastrointestinal bleed.

Monitor for bleeding; consider alternative analgesics or gastroprotective agents.

Source: KDT 7e

Corticosteroids

Severe

Textbook

Increased risk of gastrointestinal bleed.

Monitor for bleeding; consider gastroprotective agents.

Source: KDT 7e

Dapoxetine

Severe

Textbook

Increased risk of gastrointestinal bleed.

Monitor for bleeding; consider gastroprotective agents or alternative analgesics.

Source: KDT 7e

Enalaprilat

Severe

Textbook

Reduced effectiveness of ACE inhibitors. Marked hyperkalemia, potentially leading to cardiac arrhythmia.

Use with caution, especially in the elderly and in patients with hypertension, diabetes mellitus, or ischemic heart disease.

Source: G&G 14e · p836

Escitalopram + Clonazepam

Severe

Textbook

Increased risk of gastrointestinal bleed.

Monitor for bleeding; consider gastroprotective agents or alternative analgesics.

Source: KDT 7e

Glucocorticoids

Severe

Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Quinolones

Severe

Textbook

Enhanced neurological adverse effects.

Use with caution, especially in patients with a history of epilepsy.

Source: G&G 14e · p1144

Acetazolamide

Severe

Database

Drug interaction classified as: distribution