Drug reference

Clevidipine

Calcium Channel Blocker · Antihypertensive

Calcium Channel BlockerAntihypertensive

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

4 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactions

CeritinibSevereDatabaseDDInter
DolasetronSevereDatabaseDDInter
SiponimodSevereDatabaseDDInter
TizanidineSevereDatabaseDDInter

Mechanism

Clevidipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into arterial smooth muscle cells. This leads to relaxation of arterial smooth muscle and peripheral vasodilation, primarily affecting afterload. While calcium channel blockers can produce a negative inotropic effect, the significant peripheral vasodilation caused by clevidipine leads to a baroreflex-mediated increase in sympathetic tone, which helps to counteract this effect and maintain or increase cardiac output.

Indications

Hypertensive emergenciesTreatment of hypertension when oral therapy is not feasibleAcute treatment of hypertension

Dosing

Adult: in more detail in Chapter 12. Doses of calcium channel blockers used in treating hypertension are similar to those used in treating angina. Some epidemiologic studies reported an increased risk of myocardial infarction or mortality in patients receiving shortacting nifedipine for hypertension. It is therefore recommended that shortacting oral dihydropyridines not be used for hypertension.…