Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
Isradipine
Calcium Channel Blocker · Cardiovascular Agent
Calcium Channel BlockerCardiovascular Agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- ApalutamideSevereDatabaseDDInter
- CarbamazepineSevereDatabaseDDInter
- CeritinibSevereDatabaseDDInter
- DolasetronSevereDatabaseDDInter
Mechanism
Isradipine, a calcium channel antagonist, produces its effects by binding to the alpha-1 subunit of the L-type Ca2+ channels. This binding reduces Ca2+ flux through the channel, thereby altering the plateau phase of the cardiac action potential and decreasing contraction in cardiac and vascular smooth muscle cells.
Indications
Hypertension
Pharmacokinetics
Metabolism
Metabolized by CYP3A4.
Drug interactions
Carbamazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dolasetron
Severe
Database
Clinical effect not specified
Source: DDInter
Enzalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Fosphenytoin
Severe
Database
Clinical effect not specified
Source: DDInter
Itraconazole
Severe
Database
Clinical effect not specified
Source: DDInter
Lumacaftor
Severe
Database
Clinical effect not specified
Source: DDInter
Mitotane
Severe
Database
Clinical effect not specified
Source: DDInter
Phenobarbital
Severe
Database
Clinical effect not specified
Source: DDInter
Phenytoin
Severe
Database
Clinical effect not specified
Source: DDInter
Primidone
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Calcium Channel Blocker drugs
Ask House about Isradipine
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Sources: Goodman & Gilman 14e, Katzung·Verified: 2026-05-10 · House clinical team