Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
Nimodipine
Calcium Channel Blocker · Cerebrovascular Agent
Calcium Channel BlockerCerebrovascular Agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- ApalutamideSevereDatabaseDDInter
- AtazanavirSevereDatabaseDDInter
- BoceprevirSevereDatabaseDDInter
- CarbamazepineSevereDatabaseDDInter
Mechanism
Nimodipine is a dihydropyridine calcium-channel blocker.
Indications
Prevention of ischaemic neurological defects following aneurysmal subarachnoid haemorrhageTreatment of ischaemic neurological defects following aneurysmal subarachnoid haemorrhageTreatment of ischaemic neurological defects following aneurysmal subarachnoid haemorrhage in patients with unstable blood pressurePrevention and treatment of neurological deficit due to cerebral vasospasm following subarachnoid haemorrhagePrevention and treatment of neurological deficit due to ruptured congenital intracranial aneurysms
Dosing
- Adult
- Oral: 60 mg every 4 hours, to be started within 4 days of aneurysmal subarachnoid haemorrhage and continued for 21 days. Intravenous infusion (body-weight up to 70 kg): Initially up to 0.5 mg/hour, increased after 2 hours if no severe fall in blood pressure; increased to 2 mg/hour and continue for at least 5 days (max.…
- Max dose
- Oral: 360 mg/day (60 mg every 4 hours); IV: 2 mg/hour
Contraindications
- Unstable angina
- within 1 month of myocardial infarction
Side effects
Common
headacheflushingdizzinesspalpitationnausea
Serious
- Thrombocytopenia
- vasodilation
- Bradycardia
- ileus
Drug interactions
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Carbamazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clarithromycin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Cobicistat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Conivaptan
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Delavirdine
Severe
Database
Clinical effect not specified
Source: DDInter
Dolasetron
Severe
Database
Clinical effect not specified
Source: DDInter
Enzalutamide
Severe
Database
Clinical effect not specified
Source: DDInter
Fosphenytoin
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Calcium Channel Blocker drugs
Ask House about Nimodipine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Katzung, BNF, Harriet Lane·Verified: 2026-05-13 · House clinical team