Alfentanil
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Drug reference
Clomethiazole
Benzodiazepine · Sleep disorders, Ethanol withdrawal management, Preanesthetic sedation
BenzodiazepineSleep disorders, Ethanol withdrawal management, Preanesthetic sedation
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlfentanilSevereTextbookG&G 14e
- BuprenorphineSevereTextbookG&G 14e
- CodeineSevereTextbookG&G 14e
- FentanylSevereTextbookG&G 14e
Mechanism
Clomethiazole possesses sedative, muscle relaxant, and anticonvulsant properties. It is also noted to be an inducer of the cytochrome P450 enzyme CYP2E1.
Indications
Hypnosis in elderly patientsHypnosis in institutionalized patientsPreanesthetic sedationManagement of withdrawal from ethanol
Dosing
- Geriatric
- May be a useful hypnotic for elderly patients because of its freedom from hangover, but routine administration is undesirable due to dependence.
Pharmacokinetics
Metabolism
Metabolized via CYP2E1 (inducer)
Contraindications
- Concomitant use with ethanol due to adverse interactions
Side effects
Common
DependenceEffects on respiration are slight
Serious
- Deaths from adverse interactions with ethanol
Drug interactions
Buprenorphine
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Codeine
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Fentanyl
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Hydrocodone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Methadone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Methylnaltrexone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Morphine
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Nalmefene
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Naloxone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Naltrexone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Other Cns Depressants
Severe
Textbook
Typically fatal if combined in overdose.
Use with extreme caution; avoid if possible.
Source: G&G 14e
Related guidelines
Other Benzodiazepine drugs
Ask House about Clomethiazole
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team