Acetohexamide
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Drug reference
delafloxacin
Fluoroquinolone · Antibacterial
FluoroquinoloneAntibacterial
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
C
FDA category + note
Top interactionssee all 12 →
- AcetohexamideSevereDatabaseDDInter
- Bempedoic AcidSevereDatabaseDDInter
- BetamethasoneSevereDatabaseDDInter
- BupropionSevereDatabaseDDInter
Mechanism
Delafloxacin, as a fluoroquinolone, targets bacterial DNA gyrase and topoisomerase IV. It possesses potent activity against staphylococci.
Indications
Skin and soft-tissue infectionsOral therapy for skin and soft tissue infections resistant to methicillin
Pharmacokinetics
Excretion
Mixed renal and nonrenal elimination
Side effects
Common
NauseaVomitingAbdominal discomfortHeadachesDizzinessInsomniaAnxiety
Serious
- Peripheral neuropathy
- Optic neuritis
- Tendon rupture
- Tendinitis
- QT interval prolongation
- Torsades de pointes arrhythmias
- CNS stimulatory effects (including seizures)
- Glucose dysregulation
- Tendinopathy (including Achilles tendon rupture, especially in older patients, organ transplant recipients, and those on glucocorticoids)
- Increased risk of aortic aneurysm
- Worsening of myasthenia gravis
- QTc interval prolongation (moxifloxacin more likely)
Pregnancy & lactation
Pregnancy
C
Drug interactions
Bempedoic Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Betamethasone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Chlorpropamide
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Deflazacort
Severe
Database
Clinical effect not specified
Source: DDInter
Dexamethasone
Severe
Database
Clinical effect not specified
Source: DDInter
Fludrocortisone
Severe
Database
Clinical effect not specified
Source: DDInter
Glibenclamide
Severe
Database
Clinical effect not specified
Source: DDInter
Glimepiride
Severe
Database
Clinical effect not specified
Source: DDInter
Glipizide
Severe
Database
Clinical effect not specified
Source: DDInter
Hydrocortisone
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Fluoroquinolone drugs
Ask House about delafloxacin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team