Dextropropoxyphene
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
doxylamine
Antihistamine · Hypnotic
AntihistamineHypnotic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- DextropropoxypheneSevereDatabaseDDInter
- IsocarboxazidSevereDatabaseDDInter
- LevacetylmethadolSevereDatabaseDDInter
- LinezolidSevereDatabaseDDInter
Mechanism
Doxylamine is an antihistamine used for its sedative properties.
Indications
Over-the-counter nonprescription sleep aidsmorning sickness (in combination with pyridoxine)
Dosing
- Adult
- 10–20 mg at bed time; if needed additional doses may be given in morning and afternoon
Pharmacokinetics
Onset
Oral absorption is slow
Half-life
about 9 to 10 h
Side effects
Common
Prominent residual sleepiness the morning afterdrowsinessdry mouthvertigoabdominal upset
Drug interactions
Isocarboxazid
Severe
Database
Clinical effect not specified
Source: DDInter
Levacetylmethadol
Severe
Database
Clinical effect not specified
Source: DDInter
Linezolid
Severe
Database
Clinical effect not specified
Source: DDInter
Methylene Blue
Severe
Database
Clinical effect not specified
Source: DDInter
Ozanimod
Severe
Database
Clinical effect not specified
Source: DDInter
Phenelzine
Severe
Database
Clinical effect not specified
Source: DDInter
Potassium Chloride
Severe
Database
Clinical effect not specified
Source: DDInter
Potassium Citrate
Severe
Database
Clinical effect not specified
Source: DDInter
Procarbazine
Severe
Database
Clinical effect not specified
Source: DDInter
Selegiline
Severe
Database
Clinical effect not specified
Source: DDInter
Sodium Oxybate
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Antihistamine drugs
Ask House about doxylamine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team