Methylnaltrexone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Drug reference
eszopiclone
Benzodiazepine · Sedative-hypnotic
Also known as LUNESTA
BenzodiazepineSedative-hypnotic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- MethylnaltrexoneSevereTextbookG&G 14e
- NalmefeneSevereTextbookG&G 14e
- NaloxoneSevereTextbookG&G 14e
- NaltrexoneSevereTextbookG&G 14e
Mechanism
Eszopiclone exerts sedative-hypnotic effects by interacting with a subset of benzodiazepine binding sites on GABAA receptors. This interaction promotes the binding of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA) to the GABAA subtype of GABA receptors. By enhancing GABA-induced ionic currents through these multi-subunit, ligand-gated chloride channels, it produces its effects.
Indications
To facilitate sleepHypnosisAs a sedative when discontinuing sedating antihistaminic antipsychotic drugsInsomniaSleep maintenanceDecrease the latency to onset of sleeptreatment of short-term as well as chronic insomnia
Dosing
- Adult
- sometimes tried at the dose of 0.1 mg/day as a volume. increases during chronic treatment of 50-100 mg/dL are common,. with serum triglyceride levels exceeding 7000 mg/dL in some. including ziprasidone in overdose up to 12,000 mg. One exception
Pharmacokinetics
Half-life
about 6 h
Bioavailability
about 80%
Protein binding
50% to 60%
Metabolism
by CYPs 3A4 and 2E1
Excretion
Es: <10%
Side effects
Common
Bitter tasteMild withdrawal signs, consisting of abnormal dreams, anxiety, nausea, and upset stomach (≤2%)
Serious
- produces little tolerance and physical dependence
Drug interactions
Nalmefene
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Naloxone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Naltrexone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Other Cns Depressants
Severe
Textbook
Typically fatal if combined in overdose.
Use with extreme caution; avoid if possible.
Source: G&G 14e
Alfentanil
Severe
Database
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: DDInter
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Buprenorphine
Severe
Database
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Benzodiazepine drugs
Ask House about eszopiclone
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team