Nonnucleoside Reverse Transcriptase Inhibitors
Contraindicated
Textbook
Increased risk of resistance or adverse effects.
Etravirine should not be combined with other NNRTIs.
Source: G&G 14e · p1245-1266
Drug reference
Etravirine
Antiretroviral
Also known as ETR, INTELENCE, ETV
Antiretroviral
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
Manufacturer advises use only if potential
FDA category + note
Top interactionssee all 12 →
- Nonnucleoside Reverse Transcriptase InhibitorsContraindicatedTextbookG&G 14e · p1245-1266
- ValbenazineContraindicatedTextbookG&G 14e · p372
- ApalutamideSevereDatabaseDDInter
- ArtemetherSevereDatabaseDDInter
Mechanism
NNRTIs inhibit reverse transcriptase, an enzyme crucial for HIV replication. After the virus enters a host cell and uncoats, reverse transcriptase is responsible for copying the single-stranded HIV RNA genome into double-stranded DNA. By inhibiting this process, Etravirine prevents the integration of viral DNA into the host cell genome, thereby blocking the production of new infectious virions.
Indications
HIV infectionAIDSHIV-1 infection in treatment-experienced adults and children aged 2 years or older and weighing at least 10 kg with viral strains resistant to another NNRTI
Dosing
- Adult
- low-dose ritonavir (r). They boost the concentrations of other antiretrovirals metabolised by CYP3A4, but have no antiretroviral activity themselves. ANTIVIRALS › HIV-FUSION INHIBITORS Enfuvirtide l DRUG ACTION 14-Jul-2018 Enfuvirtide inhibits the fusion of HIV to the host cell.…
Pharmacokinetics
Metabolism
CYP3A4, 2C9, 2C19, UGT
Side effects
Common
rash
Serious
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
Pregnancy & lactation
Pregnancy
Manufacturer advises use only if potential
Drug interactions
Valbenazine
Contraindicated
Textbook
Potential loss of valbenazine efficacy.
Not recommended.
Source: G&G 14e · p372
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Artemether
Severe
Database
Decreased artemether levels.
Source: DDInter
Atazanavir
Severe
Database
Potentially unsafe or ineffective coadministration.
Etravirine should not be administered with atazanavir/ritonavir in the absence of better data to guide dosing.
Source: DDInter
Avapritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Axitinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Berotralstat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bosutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Brigatinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Other Antiretroviral drugs
Ask House about Etravirine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team