Cilostazole
Contraindicated
Textbook
Increased plasma levels and toxicity of cilostazole.
Should not be administered along with inhibitors of CYP3A4.
Source: KDT 7e · p555
Drug reference
Indinavir
Antiretroviral
AntiretroviralATC null
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
X
FDA category + note
Top interactionssee all 12 →
- CilostazoleContraindicatedTextbookKDT 7e · p555
- AzolesSevereTextbookHarrison 22e · p1742
- EbastineSevereTextbookKDT 7e
- AbemaciclibSevereDatabaseDDInter
Mechanism
Indinavir is an HIV protease inhibitor. It acts by binding to the active site of the HIV protease enzyme, preventing the cleavage of viral Gag and Gag-Pol polyproteins. This inhibition results in the formation of immature, non-infectious HIV particles, thereby hindering viral replication.
Indications
HIV infectionProphylaxis for HIV infection (health care workers exposed to blood by needle stick injury)HIV (in combination regimens, less frequently used now)
Dosing
- Adult
- pill containing levonorgestrel 0.15 mg + ethinylestradiol 30 μg per day cyclically (3 weeks treatment—. after sputum smear examination. She was put on isoniazid (300 mg) + rifampin (600 mg) +. pyrazinamide (1.5 g) + ethambutol (1.0 g) daily for 2 months, followed by isoniazid (600 mg). + rifampin (600 mg) thrice weekly. In the 3rd month she failed to have the usual withdrawal.…
Pharmacokinetics
Half-life
2–8 hours (plasma)
Bioavailability
~65% (oral)
Metabolism
Primarily metabolized by CYP3A4.
Excretion
Excreted via ABC transporters MDR1 (ABCB1) and MRP2 (ABCC2).
Side effects
Common
g.i. intolerancehyperbilirubinaemia
Serious
- crystallizes in urine (increases risk of urinary calculi)
Pregnancy & lactation
Pregnancy
X
Drug interactions
Azoles
Severe
Textbook
Increased plasma levels of indinavir (by azoles); increased azole plasma levels (by indinavir).
Source: Harrison 22e · p1742
Ebastine
Severe
Textbook
Increased risk of arrhythmogenic potential.
Exercise caution with coadministration.
Source: KDT 7e
Abemaciclib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Acalabrutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Alfentanil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Alfuzosin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Alprazolam
Severe
Database
Significantly increased alprazolam plasma concentrations, leading to enhanced sedative and psychomotor effects.
Avoid concomitant use. If co-administration is unavoidable, reduce alprazolam dose by 50-75% and monitor for increased sedation.
Source: DDInter
Amiodarone
Severe
Database
Increase amiodarone levels.
Source: DDInter
Artemether
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Astemizole
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Related guidelines
Antiretroviral therapy for HIV
NACO · Infectious Diseases · 2018
Blood transfusion in obstetrics and gynaecology
FOGSI · Obstetrics & Gynaecology · 2024
Skin and soft tissue infections
IDSA · Infectious Diseases · 2010
Hepatitis B — chronic infection
EASL · Gastroenterology · 2025
Urinary tract infection
EAU · Urology · 2024
Other Antiretroviral drugs
Ask House about Indinavir
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-13 · House clinical team