isosorbide dinitrate/hydralazine

Isosorbide dinitrate, an organic nitrate, dilates large blood vessels (venous capacitance and arterial conductance vessels), primarily reducing preload. Hydralazine is a direct vasodilator whose mechanism of action is unresolved but may prevent nitrate tolerance by reducing ROS-mediated inactivation of nitric oxide.

Adult

Fixed combination formulation contains 37.5 mg hydralazine and 20 mg ISDN and is uptitrated to a target dose of two tablets, thrice daily.

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