Lamivudine + Zidovudine

Combivir is a fixed-dose combination of zidovudine and lamivudine, both nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs are nucleoside analogues that, after intracellular phosphorylation, inhibit HIV reverse transcriptase, thereby blocking viral DNA synthesis and replication.

Adult

1 tablet twice daily

Renal adjustment

Avoid if eGFR less than 50 mL/minute/1.73 m2

• eGFR less than 50 mL/minute/1.73 m2