Lopinavir with ritonavir

Lopinavir with ritonavir is a combination of protease inhibitors used in the treatment of HIV infection. Protease inhibitors work by binding to the active site of the HIV-1 protease enzyme, thereby preventing the proteolytic cleavage of Gag and Gag-Pol polyproteins. This inhibition results in the production of immature, non-infectious viral particles, disrupting the viral life cycle.

Adult

By mouth using tablets: 400/100 mg twice daily, alternatively 800/200 mg once daily (once daily dose to be used only in adults with a HIV strain that has less than 3 mutations to protease inhibitors). By mouth using oral solution: 5 mL twice daily.

• Cardiac conduction disorders
• Pancreatitis
• Patients at high risk of cardiovascular disease
• Structural heart disease