Antihistamine · Allergy Relief
Loratadine is a second-generation, non-sedating antihistamine that works by blocking histamine H1 receptors. It achieves far lower brain concentrations than older antihistamines due to its minimal penetration of the blood-brain barrier. This reduced central nervous system penetration leads to less sedation and psychomotor impairment.
Most manufacturers advise avoiding antihistamine use during pregnancy, though there is no evidence of teratogenicity.
Most antihistamines are present in breast milk in varying amounts; manufacturers generally advise avoiding their use in breastfeeding mothers, although harm is not known.
Increased risk of dose-related adverse effects of loratadine, such as sedation, headache, and dry mouth. While loratadine is generally non-sedating, higher concentrations could potentially lead to more pronounced CNS effects.
Monitor for increased adverse effects. Consider a lower dose of loratadine if co-administration is necessary and adverse effects occur. Patients should be advised about the potential for increased sedation.
Increased risk of dose-related adverse effects of loratadine, such as sedation, headache, and dry mouth. Although loratadine is generally non-sedating, higher concentrations might enhance these effects.
Monitor for increased adverse effects. If co-administration is necessary, advise patients about the potential for increased sedation and other side effects. Dose adjustment of loratadine is generally not required unless adverse effects are prominent.
Source: DDInter
Increased risk of dose-related adverse effects of loratadine, such as sedation, headache, and dry mouth. Although loratadine is generally non-sedating, higher concentrations might enhance these effects.
Monitor for increased adverse effects. If co-administration is necessary, advise patients about the potential for increased sedation and other side effects. Dose adjustment of loratadine is generally not required unless adverse effects are prominent.
Source: DDInter
Increased risk of dose-related adverse effects of loratadine, such as sedation, headache, and dry mouth. Although loratadine is generally non-sedating, higher concentrations might enhance these effects.
Monitor for increased adverse effects. If co-administration is necessary, advise patients about the potential for increased sedation and other side effects. Dose adjustment of loratadine is generally not required unless adverse effects are prominent.
Source: DDInter
Increased risk of dose-related adverse effects of loratadine, such as sedation, headache, and dry mouth. While loratadine is generally non-sedating at recommended doses, higher concentrations could potentially lead to more pronounced CNS effects.
Monitor for increased adverse effects. Consider a lower dose of loratadine if co-administration is necessary and adverse effects occur. Patients should be advised about the potential for increased sedation.
Source: DDInter
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Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-13 · House clinical team