Adrenaline
Severe
Textbook
Marked rise in BP.
Adrenaline should not be given to patients receiving β blockers.
Source: KDT 7e · p133
Drug reference
Metipranolol
Beta Blocker · Antiglaucoma agent
Beta BlockerAntiglaucoma agentATC S01ED06
CDSCO approvedSchedule HATC S01ED06
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AdrenalineSevereTextbookKDT 7e · p133
- AmilorideSevereTextbookKDT 7e
- SofosbuvirSevereTextbookHarrison 22e · unknown
- AminophyllineSevereDatabaseDDInter
Mechanism
Metipranolol is a non-selective beta-adrenergic receptor antagonist. When applied topically to the eye, it decreases aqueous humor secretion from the ciliary epithelium, thereby reducing intraocular pressure.
Indications
Open-angle glaucomaGlaucoma (topical)
Dosing
- Adult
- Propranolol is the prototypical βblocking drug (See Table 10–2). As noted above, it has low and dosedependent bioavailability. A longacting form of propranolol is available, with absorption of the drug occurring over a 24hour period.…
Contraindications
- Bradycardia
- Heart block
- Heart failure
- Asthma
- Obstructive airway disease
Drug interactions
Amiloride
Severe
Textbook
Hyperkalaemia more likely.
Source: KDT 7e
Sofosbuvir
Severe
Textbook
Severe bradycardia.
Extreme caution advised if amiodarone is co-administered with sofosbuvir and a beta blocker.
Source: Harrison 22e · unknown
Aminophylline
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Arformoterol
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clonidine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Diltiazem
Severe
Database
Increased propensity for AV block, severe bradycardia, and decreased left ventricular function.
Avoid concurrent administration. The concurrent administration of diltiazem with a beta blocker is contraindicated.
Source: DDInter
Dyphylline
Severe
Database
Clinical effect not specified
Source: DDInter
Epinephrine
Severe
Database
Severe hypertension and cerebral hemorrhage.
The use of epinephrine generally is contraindicated in patients who are receiving nonselective β receptor antagonists.
Source: DDInter
Formoterol
Severe
Database
Clinical effect not specified
Source: DDInter
Indacaterol
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Beta Blocker drugs
Ask House about Metipranolol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Katzung·Verified: 2026-05-13 · House clinical team