Miconazole

Miconazole is an imidazole antifungal that inhibits fungal lanosterol 14-α-demethylase (CYP51), depleting ergosterol from cell membranes and causing accumulation of toxic methylated sterol intermediates. At higher concentrations, it also directly damages fungal cell membranes by interacting with membrane phospholipids. Unlike the systemically used triazoles, miconazole is primarily used topically due to its less selective inhibition of mammalian cytochrome P450 enzymes; however, even topical oral gel formulations can inhibit CYP2C9 sufficiently to potentiate warfarin.

Adult

midazolam p. 356 by subcutaneous infusion using a continuous infusion device see below. Dry mouth Dry mouth may be relieved by good mouth care and measures such as chewing sugar-free gum, sucking ice or pineapple chunks, or the use of artificial saliva,dry mouth associated with candidiasis can be treated by oral preparations of nystatin p. 1284 or miconazole p. 876, alternatively, fluconazole p.…

• Concomitant use with anticoagulants (e.g., warfarin) due to potential for serious drug interactions