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Molindone

Atypical Antipsychotic · Antipsychotic

Also known as Molindone hydrochloride

Atypical AntipsychoticAntipsychotic
CDSCO approvedSchedule X
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
not curated
Top interactionssee all 12
  • AlfentanilSevereDatabaseDDInter
  • BenzhydrocodoneSevereDatabaseDDInter
  • BuprenorphineSevereDatabaseDDInter
  • BupropionSevereDatabaseDDInter

Mechanism

Molindone is a first-generation antipsychotic. The textbook indicates its potencies at neurotransmitter receptors, suggesting its therapeutic effects are mediated through interactions with these receptors.

Indications

Schizophrenia Spectrum Disorders

Dosing

Adult
Most antipsychotic drugs are readily but incompletely absorbed. Furthermore, many undergo significant first­pass metabolism. Thus, oral doses of chlorpromazine and thioridazine have systemic availability of 25–35%, whereas haloperidol, which has less first­pass metabolism, has an average systemic availability of about 65%.…

Side effects

Serious
  • Tardive dyskinesia

Drug interactions

Alfentanil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Benzhydrocodone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Buprenorphine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bupropion
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Butorphanol
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Clozapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Codeine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Deutetrabenazine
Severe
Database

Clinical effect not specified

Source: DDInter

Dextropropoxyphene
Severe
Database

Clinical effect not specified

Source: DDInter

Dezocine
Severe
Database

Clinical effect not specified

Source: DDInter

Dihydrocodeine
Severe
Database

Clinical effect not specified

Source: DDInter

Fentanyl
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Other Atypical Antipsychotic drugs

Ask House about Molindone

Continue into a citation-backed clinical answer with the drug context already attached.

Sources: Katzung·Verified: 2026-05-13 · House clinical team