Drug reference

oral poliovirus vaccine

live attenuated virus vaccine · vaccine

live attenuated virus vaccinevaccine

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

The oral poliovirus vaccine (Sabin vaccine) is a live attenuated vaccine containing attenuated poliovirus types I, II, and III. It replicates in the intestine, inducing systemic and mucosal immunity, and is shed in stool, contributing to herd immunity.

Indications

prevention of poliomyelitisActive immunization against poliomyelitisElimination of carrier state of poliovirus

Dosing

Pediatric: Each dose is 2 drops, dropped directly in the mouth. Primary immunization: at birth, then at 6, 10 and 14 weeks. Booster doses: between 15–18 months and at school entry.

Contraindications

subjects with primary immunodeficiency
pregnant women
children with symptomatic HIV infection
Vomiting
Diarrhoea

Side effects

Serious

Rarely (about one case per million doses), partial revertant viruses occur that cause vaccine-associated paralytic poliomyelitis in contacts.
Vaccine associated paralysis (extremely rarely)