Adrenaline
Severe
Textbook
Marked rise in BP.
Adrenaline should not be given to patients receiving β blockers.
Source: KDT 7e · p133
Drug reference
Pindolol
Beta Blocker · Antihypertensive
Beta BlockerAntihypertensiveATC C07AA03
CDSCO approvedSchedule HATC C07AA03
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AdrenalineSevereTextbookKDT 7e · p133
- AmilorideSevereTextbookKDT 7e
- SofosbuvirSevereTextbookHarrison 22e · unknown
- AminophyllineSevereDatabaseDDInter
Mechanism
Pindolol is a beta-adrenoceptor blocker that possesses intrinsic sympathomimetic activity (partial agonist activity). It stimulates as well as blocks adrenergic receptors. This allows it to prevent overstimulation of the heart by endogenous catecholamines while assuring slight receptor stimulation in patients sensitive to negative inotropic and chronotropic effects of beta blockade.
Indications
Hypertensionangina pectoris
Dosing
- Adult
- Initially 2.5–5 mg up to 3 times a day by mouth.
Pharmacokinetics
Half-life
about 4 h
Bioavailability
moderately high, almost completely absorbed after oral administration
Protein binding
clearance reduced in patients with renal failure
Metabolism
approximately 50% metabolized in the liver
Excretion
remainder excreted unchanged in urine
Contraindications
- Second- or third-degree heart block
- Worsening unstable heart failure
- abrupt discontinuation (withdrawal syndrome)
Drug interactions
Amiloride
Severe
Textbook
Hyperkalaemia more likely.
Source: KDT 7e
Sofosbuvir
Severe
Textbook
Severe bradycardia.
Extreme caution advised if amiodarone is co-administered with sofosbuvir and a beta blocker.
Source: Harrison 22e · unknown
Aminophylline
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Arformoterol
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clonidine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Diltiazem
Severe
Database
Increased propensity for AV block, severe bradycardia, and decreased left ventricular function.
Avoid concurrent administration. The concurrent administration of diltiazem with a beta blocker is contraindicated.
Source: DDInter
Disopyramide
Severe
Database
Clinical effect not specified
Source: DDInter
Dolasetron
Severe
Database
Clinical effect not specified
Source: DDInter
Dyphylline
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Beta Blocker drugs
Ask House about Pindolol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team