Methylnaltrexone
Severe
Textbook
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: G&G 14e
Drug reference
quazepam
Benzodiazepine · Hypnotic
BenzodiazepineHypnotic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- MethylnaltrexoneSevereTextbookG&G 14e
- NalmefeneSevereTextbookG&G 14e
- NaloxoneSevereTextbookG&G 14e
- NaltrexoneSevereTextbookG&G 14e
Mechanism
All benzodiazepines in clinical use promote the binding of the major inhibitory neurotransmitter GABA to the GABAA receptor, a pentameric ligand-gated, anion-conducting channel. Benzodiazepines are allosteric modulators of GABAA receptor function, increasing the affinity of the GABAA receptor for GABA and thereby enhancing GABA-induced Cl– currents.
Indications
Insomnia
Dosing
- Adult
- 7.5–15 mg
Pharmacokinetics
Half-life
39
Metabolism
Active metabolites accumulate with chronic use
Drug interactions
Nalmefene
Severe
Textbook
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: G&G 14e
Naloxone
Severe
Textbook
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: G&G 14e
Naltrexone
Severe
Textbook
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: G&G 14e
Other Cns Depressants
Severe
Textbook
Excessive impairment.
Source: KDT 7e · p406
Alfentanil
Severe
Database
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Buprenorphine
Severe
Database
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Codeine
Severe
Database
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: DDInter
Dextropropoxyphene
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Benzodiazepine drugs
Ask House about quazepam
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team