Enalapril
Contraindicated
Database
Increased rate of angioedema, a rare but life-threatening condition.
The combination is contraindicated. Discontinue ACEI or ARB, and then add ARNI.
Drug reference
sacubitril
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
3 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactions
- EnalaprilContraindicatedDatabase
- PerindoprilContraindicatedDatabaseKimi deep-research + Cla
- MoexiprilSevereDatabaseDDInter
Mechanism
Sacubitril is an inhibitor of neprilysin, an enzyme that degrades ANP and BNP.
Indications
heart failure
Pharmacokinetics
Half-life
LBQ657, which has a t1/2 of 11 h
Bioavailability
about 60%
Protein binding
highly protein bound (94%–97%)
Metabolism
metabolized by esterases into the active metabolite LBQ657
Drug interactions
Perindopril
Contraindicated
Database
Additive angioedema risk (dual neprilysin/ACE)
Do not combine; ≥36 h washout
Source: Kimi deep-research + Cla
Moexipril
Severe
Database
Clinical effect not specified
Source: DDInter
9 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
Other Unclassified drugs
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10