Sertaconazole

Sertaconazole, an imidazole antifungal, inhibits the fungal cytochrome P450 enzyme 14 -demethylase, which converts lanosterol to ergosterol. Ergosterol is essential for the fungal cell membrane; its depletion and the accumulation of toxic intermediate sterols increase membrane permeability and lead to fungal cell death. At topical concentrations, azoles may also directly increase fungal cytoplasmic membrane permeability.

Adult

Pharmacokinetic studies indicate that 1–2% of the dose is absorbed when applied as a solution on the back under an occlusive dressing. Ciclopirox Adverse local reactions to the imidazoles may include stinging, pruritus, erythema, and local irritation. Allergic contact dermatitis is uncommon.…