Desogestrel
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Sugammadex
Antidote · Neuromuscular blockade reversal
AntidoteNeuromuscular blockade reversal
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
10 major
SEVERE in our sources
PREGNANCY
Use with caution—no information available.
FDA category + note
Top interactionssee all 10 →
- DesogestrelSevereDatabaseDDInter
- DienogestSevereDatabaseDDInter
- DrospirenoneSevereDatabaseDDInter
- EtonogestrelSevereDatabaseDDInter
Mechanism
Sugammadex is a modified gamma cyclodextrin that acts by encapsulating the neuromuscular blocking agents rocuronium bromide or vecuronium bromide, thereby rapidly reversing their effects.
Indications
Routine reversal of neuromuscular blockade induced by rocuronium or vecuroniumImmediate reversal of neuromuscular blockade induced by rocuroniumRapid reversal of neuromuscular blockade in an emergencyreversal of paralysis induced by rocuroniumrapid reversal of rocuronium- and vecuronium-induced neuromuscular block
Dosing
- Adult
- Routine reversal of neuromuscular blockade induced by rocuronium or vecuronium: Initially 2–4 mg/kg by intravenous injection, then 4 mg/kg if required for recurrence of neuromuscular blockade. Immediate reversal of neuromuscular blockade induced by rocuronium: 16 mg/kg by intravenous injection.
- Renal adjustment
- Avoid if eGFR less than 30 mL/minute/1.73 m2.
- Geriatric
- Recovery may be delayed in the elderly.
Contraindications
- Renal impairment (eGFR less than 30 mL/minute/1.73 m2)
Side effects
Common
Abdominal painArrhythmiasCoughDizzinessHeadacheNauseaProcedural complicationsSkin reactionsTaste alteredVomiting
Serious
- Hypersensitivity
- Bronchospasm
- Angioedema
- Face oedema
- Malignant
Pregnancy & lactation
Pregnancy
Use with caution—no information available.
Drug interactions
Dienogest
Severe
Database
Clinical effect not specified
Source: DDInter
Drospirenone
Severe
Database
Clinical effect not specified
Source: DDInter
Etonogestrel
Severe
Database
Clinical effect not specified
Source: DDInter
Levonorgestrel
Severe
Database
Clinical effect not specified
Source: DDInter
Medroxyprogesterone Acetate
Severe
Database
Clinical effect not specified
Source: DDInter
Norelgestromin
Severe
Database
Clinical effect not specified
Source: DDInter
Norethisterone
Severe
Database
Clinical effect not specified
Source: DDInter
Norgestimate
Severe
Database
Clinical effect not specified
Source: DDInter
Norgestrel
Severe
Database
Clinical effect not specified
Source: DDInter
2 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Other Antidote drugs
Ask House about Sugammadex
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Sources: Goodman & Gilman 14e, Katzung, BNF, Harriet Lane·Verified: 2026-05-10 · House clinical team