Methylnaltrexone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Drug reference
Temazepam
Benzodiazepine · Sedative-hypnotic
BenzodiazepineSedative-hypnotic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
[MHRA/CHM advice].
. Multiple sclerosis p. 893 and Nausea and labyrinth
FDA category + note
Top interactionssee all 12 →
- MethylnaltrexoneSevereTextbookG&G 14e
- NalmefeneSevereTextbookG&G 14e
- NaloxoneSevereTextbookG&G 14e
- NaltrexoneSevereTextbookG&G 14e
Mechanism
Benzodiazepines exert their effects by binding to the GABAA receptor, enhancing gamma-aminobutyric acid (GABAergic) neurotransmission. This interaction increases the frequency of chloride channel opening, leading to neuronal depression at various levels of the neuraxis. The benzodiazepine antagonist flumazenil can reverse or prevent these effects by competing for GABAA receptor binding.
Indications
Insomniasleep onset difficultyfor individuals who react unfavourably to unfamiliar surroundings or unusual timings of sleep
Dosing
- Adult
- Insomnia: 10-20 mg at bedtime; 30-40 mg in exceptional circumstances only.
- Max dose
- 40 mg at bedtime
Pharmacokinetics
Duration
Free of residual effects. Accumulation can occur on daily ingestion.
Half-life
11 ± 6
Bioavailability
Absorption is slow in tablet form but fast when used in soft gelatin capsule
Metabolism
Metabolized mainly by conjugation
Excretion
Crosses placenta
Contraindications
- obstructive sleep apnoea
Side effects
Common
dizzinessvertigoataxiadisorientationamnesiaprolongation of reaction time (impairment of psychomotor skills)hangover (less common than with barbiturates)weaknessblurring of visiondry mouthurinary incontinence
Serious
- Potentially fatal respiratory depression
- Allergic reactions
- Hepatotoxic reactions
- Hematologic reactions
Pregnancy & lactation
Pregnancy
[MHRA/CHM advice]. . Multiple sclerosis p. 893 and Nausea and labyrinth
Lactation
Secreted in milk
Drug interactions
Nalmefene
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Naloxone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Naltrexone
Severe
Textbook
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Other Cns Depressants
Severe
Textbook
Typically fatal if combined in overdose.
Use with extreme caution; avoid if possible.
Source: G&G 14e
Alfentanil
Severe
Database
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Buprenorphine
Severe
Database
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Codeine
Severe
Database
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: DDInter
Dextropropoxyphene
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Benzodiazepine drugs
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Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e, BNF·Verified: 2026-05-10 · House clinical team