Itraconazole
Contraindicated
Database
Profound and prolonged sedation, respiratory depression.
Concomitant use is contraindicated. If a benzodiazepine is required, consider one not metabolized by CYP3A4.
Source: DDInter
Drug reference
Triazolam
Antiplatelet · Unknown
AntiplateletUnknown
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- ItraconazoleContraindicatedDatabaseDDInter
- KetoconazoleContraindicatedDatabaseDDInter
- AzolesSevereTextbookHarrison 22e · p1742
- AlfentanilSevereDatabaseDDInter
Mechanism
Triazolam antagonizes some actions of Platelet Activating Factor (PAF). PAF is a potent mediator involved in inflammation, increasing vascular permeability, causing vasodilatation and bronchoconstriction. By blocking PAF receptors, Triazolam may mitigate these effects, which are implicated in various pathological states such as bronchial asthma and anaphylactic shock.
Indications
Insomniasleep inductionfor elderly patients, shift workers, travellers
Dosing
- Adult
- Caps: 75, 150, 300 mg. Oral solution: 75 mg/5 mL (100 mL); may contain ethyl parabens. Injection: 150 mg/mL (2, 4, 6, 60 mL); contains 9.45 mg/mL benzyl alcohol. Premixed injection in 5% dextrose or NS: 300 mg/50 mL, 600 mg/50 mL, 900 mg/50 mL; contains. Solution, topical: 1% (30, 60 mL); may contain 50% isopropyl alcohol and propylene glycol
Pharmacokinetics
Onset
Peak effect occurs in < 1 hour
Duration
Does not accumulate on repeated nightly use; no residual effects in the morning
Half-life
2.9 ± 1.0
Metabolism
Primarily metabolized by CYP3A4/5 enzymes.
Excretion
Crosses placenta
Contraindications
- obstructive sleep apnoea
Side effects
Common
May cause disturbing daytime side effectsEarly morning insomniaRebound insomnia on drug discontinuationAnterograde amnesia (more common)waking up early and feeling anxiousrebound insomnia (on discontinuation)
Serious
- Allergic reactions
- Hepatotoxic reactions
- Hematologic reactions
- Increased incidence of confusion and abnormal behaviors
- alteration of sleep architecture (higher doses)
- anterograde amnesia (higher doses)
- anxiety the following day (higher doses)
- paranoia
- psychiatric disturbances
Pregnancy & lactation
Lactation
Secreted in milk
Drug interactions
Ketoconazole
Contraindicated
Database
Markedly increased and prolonged sedative effects, respiratory depression.
Concomitant use is contraindicated. If a benzodiazepine is needed, consider one not metabolized by CYP3A4.
Source: DDInter
Azoles
Severe
Textbook
Increased plasma levels of triazolam.
Source: Harrison 22e · p1742
Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Buprenorphine
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Antiplatelet drugs
Ask House about Triazolam
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e, Harriet Lane·Verified: 2026-05-10 · House clinical team