Umeclidinium
Antimuscarinic · Bronchodilator
Also known as Umeclidinium bromide
Mechanism
Umeclidinium is a long-acting antimuscarinic agent, a synthetic analog of atropine. It acts as a bronchodilator by slowly dissociating from M3 receptors on bronchial smooth muscle cells. This action helps to reduce bronchoconstriction and allows for once-daily administration due to its prolonged effect.
Indications
Dosing
- Adult
- 55 micrograms once daily by inhalation of powder
- Hepatic adjustment
- Manufacturer advises caution in severe impairment
Pharmacokinetics
Side effects
- Eye pain
Pregnancy & lactation
Manufacturer advises use only if potential benefit outweighs risk
Manufacturer advises avoid—no information available
Drug interactions
12 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
Other Antimuscarinic drugs
Ask House about Umeclidinium
Continue into a citation-backed clinical answer with the drug context already attached.
Textbook-sourced·Sources: Goodman & Gilman 14e, Katzung, BNF·Updated: 2026-05-10