Bexarotene
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
Dienogest
Progestogen · Endometriosis treatment
Also known as Zalkya
ProgestogenEndometriosis treatment
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- BexaroteneSevereDatabaseDDInter
- BoceprevirSevereDatabaseDDInter
- BosentanSevereDatabaseDDInter
- BrigatinibSevereDatabaseDDInter
Mechanism
Dienogest is a nortestosterone derivative that has a progestogenic effect in the uterus, reducing the production of estradiol and thereby suppressing endometriotic lesions.
Indications
Endometriosis
Dosing
- Adult
- 2 mg orally once daily for females of childbearing potential. If one or more tablets are missed, or if vomiting and/or diarrhoea occurs within 3–4 hours of taking a tablet, another tablet should be taken as soon as possible and the next dose taken at the normal time.
- Hepatic adjustment
- Avoid in severe impairment (no information available).
Contraindications
- Severe hepatic impairment
Pregnancy & lactation
Lactation
Manufacturer advises avoid—present in milk in animal studies.
Drug interactions
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bosentan
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Brigatinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Carbamazepine
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Dabrafenib
Severe
Database
Clinical effect not specified
Source: DDInter
Encorafenib
Severe
Database
Clinical effect not specified
Source: DDInter
Eslicarbazepine
Severe
Database
Clinical effect not specified
Source: DDInter
Felbamate
Severe
Database
Clinical effect not specified
Source: DDInter
Fosamprenavir
Severe
Database
Clinical effect not specified
Source: DDInter
Fosphenytoin
Severe
Database
Clinical effect not specified
Source: DDInter
Griseofulvin
Severe
Database
Clinical effect not specified
Source: DDInter
Other Progestogen drugs
Ask House about Dienogest
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Katzung, BNF, Nelson·Verified: 2026-05-10 · House clinical team