Drug reference

Ethinylestradiol; Norelgestromin

Progestogen · Contraception

Also known as ORTHO EVRA, Ethinylestradiol, Norelgestromin, Evra

ProgestogenContraception

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

US XULANE label: XULANE is a combined hormonal transdermal contraceptive that suppresses gonadotropins, primarily inhibiting ovulation; cervical mucus and endometrial changes also contribute.

Indications

US XULANE prevents pregnancy in women with BMI <30 kg/m² for whom a combined hormonal contraceptive is appropriate; contraindicated at BMI ≥30 kg/m² and in smokers older than 35. It may be less effective at weight ≥90 kg.Contraception in women who are likely to comply poorly with combined oral contraceptives (restricted use)

Dosing

Adult: Apply one patch weekly to the buttock, abdomen, upper arm, or torso for 3 consecutive weeks, followed by one patch-free week, completing a 28-day cycle.…

Pharmacokinetics

Duration

Weekly

Bioavailability

Higher estrogen exposure (AUC) than low-dose oral contraceptive pills

Metabolism

US XULANE label: Norelgestromin undergoes hepatic metabolism to norgestrel and hydroxylated/conjugated metabolites; transdermal delivery bypasses first-pass absorption metabolism.