Desogestrel

Desogestrel, a 19-nor testosterone derivative (gonane), functions primarily through its progestational activity. Its major mechanism of action involves a progesterone-mediated decrease in GnRH pulse frequency, which is critical for suppressing gonadotropin release. This suppression of gonadotropins ultimately resets the hypothalamic-pituitary-gonadal axis, preventing ovulation.

Adult

For combined oral contraceptives, typically 150 micrograms Desogestrel with 20 micrograms Ethinylestradiol (e.g., Gedarel 20/150, Mercilon) or 150 micrograms Desogestrel with 30 micrograms Ethinylestradiol (e.g., Gedarel 30/150, Marvelon), administered as 21-day preparations.

• Complete loss of vision or sudden disturbance of hearing or other perceptual disorders
• Dysphasia
• Bad fainting attack or collapse
• First unexplained epileptic seizure
• Weakness, motor disturbances, or very marked numbness suddenly affecting one side or one part of body
• Hepatitis
• Jaundice
• Liver enlargement
• Blood pressure above systolic 160 mmHg or diastolic 95 mmHg
• Prolonged immobility after surgery or leg injury
• Detection of a risk factor which contra-indicates treatment