Drug reference

Drospirenone

Progestogen · Contraception

Also known as Yasmin

ProgestogenContraception

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

Manufacturer advises not to be initiated

FDA category + note

Top interactionssee all 12 →

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Mechanism

Drospirenone is a progestogen component of combined hormonal contraceptives used for effective contraception.

Indications

Contraception (as a component of combined oral contraceptives)Hormonal contraception in women of childbearing potential when using elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide, provided the contraceptive contains at least 30 micrograms ethinylestradiolhormonal contraceptionprogestin-only contraception

Dosing

Adult: Missed doses Manufacturer advises if a dose is more than 18 hours late, the missed dose should not be taken and the next dose should be taken at the normal time. Driving and skilled tasks Manufacturer advises patients and carers should be counselled on the effects on driving and performance of skilled tasks—increased risk of dizziness.…

Contraindications

Avoid combined hormonal contraception if two or more risk factors for venous thromboembolism are present, including: family history of VTE in a first-degree relative aged under 45 years (especially with known prothrombotic coagulation abnormality e.g., factor V Leiden or antiphospholipid antibodies); obesity (BMI >= 30 kg/m2, avoid if BMI >= 35 kg/m2 unless no suitable alternative; caution in markedly obese adolescents).
Avoid combined hormonal contraception if two or more risk factors for arterial disease are present, including: family history of arterial disease in a first-degree relative aged under 45 years.
undiagnosed vaginal bleeding
benign or malignant liver disease
known or suspected breast cancer