Abarelix
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Dolasetron
Antiemetic
Also known as Anzemet
AntiemeticATC A04AA04
CDSCO approvedSchedule HATC A04AA04
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
and should be avoided in women ofPage
FDA category + note
Top interactionssee all 12 →
- AbarelixSevereDatabaseDDInter
- AbirateroneSevereDatabaseDDInter
- AcebutololSevereDatabaseDDInter
- AdenosineSevereDatabaseDDInter
Mechanism
Dolasetron is a 5-HT3 receptor antagonist. It blocks 5-HT3 receptors in the gastrointestinal tract, which activate visceral afferent pain sensation, thereby reducing unpleasant visceral afferent sensations including nausea. It also blocks central 5-HT3 receptors, reducing the central response to visceral afferent stimulation.
Indications
Chemotherapy-induced nauseaNausea and vomitingNauseasuppressing nausea and vomitingChemotherapy-induced nausea and vomitingPostoperative nausea and vomiting (PONV)Nausea secondary to upper abdominal irradiationHyperemesis of pregnancyPrevention of chemotherapy-induced nausea and vomiting (severely emetogenic regimens)
Dosing
- Adult
- In a dosage of 1 mg once or twice daily, alosetron reduces IBSrelated lower abdominal pain, cramps, urgency, and diarrhea. Approximately 50–60% of patients report adequate relief of pain and discomfort with alosetron compared with 30–40% of patients treated with placebo. It also leads to a reduction in the mean number of bowel movements per day and improvement in stool consistency.…
Pharmacokinetics
Half-life
6 to 8 h (for active metabolite hydrodolasetron)
Metabolism
Rapidly converted by plasma carbonyl reductase to active metabolite hydrodolasetron; subsequently biotransformed by CYP2D6 and CYP3A4 in the liver
Excretion
About one-third excreted unchanged in urine (as hydrodolasetron)
Contraindications
- Prophylactic therapy for chemotherapy-induced nausea and vomiting (injectable form due to risk of QT prolongation)
Side effects
Common
Constipation or diarrheaHeadacheLight-headedness
Serious
- ECG interval changes (QT prolongation)
- Serotonin syndrome
Pregnancy & lactation
Pregnancy
and should be avoided in women ofPage
Drug interactions
Abiraterone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Acebutolol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Adenosine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfuzosin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alimemazine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Almotriptan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amlodipine
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Related guidelines
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FOGSI · Obstetrics & Gynaecology · 2024
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ICMR · Obstetrics & Gynaecology · 2022
Hypertensive disorders of pregnancy
FOGSI · Obstetrics & Gynaecology · 2019
Iron deficiency anaemia in pregnancy
FOGSI · Obstetrics & Gynaecology · 2017
Other Antiemetic drugs
Ask House about Dolasetron
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Textbook-sourced·Sources: Goodman & Gilman 14e, Harrison 22e, Katzung·Updated: 2026-05-13