Acalabrutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
Fosaprepitant
Antiemetic
Also known as EMEND
AntiemeticATC A04AD13
CDSCO approvedSchedule HATC A04AD13
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
Nausea in the first trimester of pregnancy is generally mild
FDA category + note
Top interactionssee all 12 →
- AcalabrutinibSevereDatabaseDDInter
- AlfentanilSevereDatabaseDDInter
- AstemizoleSevereDatabaseDDInter
- AvanafilSevereDatabaseDDInter
Mechanism
Fosaprepitant is a prodrug that is converted to aprepitant after intravenous administration. Aprepitant is an antagonist of the neurokinin 1 (NK1) receptor. It blocks the binding of Substance P (SP), the preferred ligand for the NK1 receptor, which mediates central and peripheral effects related to emesis.
Indications
Prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin-based chemotherapyPrevention of nausea and vomiting associated with moderately emetogenic chemotherapyPrevention of chemotherapy-induced nausea and vomiting (delayed phase)Prevention of postoperative nausea and vomiting (PONV)antiemetic
Dosing
- Adult
- ▶ BY RECTUM ▶ Antiemetics should be given to prevent motion sickness rather than after nausea or vomiting develop. The most effective drug for the prevention of motion sickness is hyoscine hydrobromide p. 458. The sedating antihistamines are slightly less effective against motion sickness, but are generally better tolerated than hyoscine.…
Pharmacokinetics
Half-life
9-13 hours (as aprepitant)
Protein binding
Extensively bound to plasma proteins (>95%) (as aprepitant)
Metabolism
Metabolized avidly, primarily by hepatic CYP3A4 (as aprepitant)
Excretion
Excreted in the stools (as aprepitant)
Contraindications
- Concomitant use with cisapride
- Concomitant use with pimozide
- Patients receiving cisapride, terfenadine, astemizole, or pimozide
Side effects
Common
FatigueConstipationHiccups
Serious
- Life-threatening QT prolongation (when co-administered with cisapride or pimozide)
Pregnancy & lactation
Pregnancy
Nausea in the first trimester of pregnancy is generally mild
Drug interactions
Alfentanil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Astemizole
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Avanafil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Avapritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bosutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Brexpiprazole
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Brigatinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Cilostazol
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Cisapride
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Other Antiemetic drugs
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Textbook-sourced·Sources: KD Tripathi 7e, Goodman & Gilman 14e, BNF·Updated: 2026-05-13