Drug reference

Flurbiprofen

NSAID · Analgesic, Anti-inflammatory

NSAIDAnalgesic, Anti-inflammatory

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

Avoid during pregnancy (warning for topical preparations)

FDA category + note

Top interactionssee all 12 →

AminoglycosideSevereTextbookKDT 7e · p746
AminoglycosidesSevereTextbookKDT 7e
AnticoagulantsSevereTextbookKDT 7e
CorticosteroidsSevereTextbookKDT 7e

Mechanism

Flurbiprofen, as a non-steroidal anti-inflammatory drug (NSAID), reduces the production of prostaglandins by inhibiting the enzyme cyclo-oxygenase.

Indications

Pain and inflammation in rheumatic disease and other musculoskeletal disordersMigrainePostoperative analgesiaMild to moderate painSymptomatic treatment of rheumatoid arthritisOsteoarthritisunwanted intraoperative miosis during cataract surgeryrheumatoid arthritismusculoskeletal disordersocular antiinflammatory (noninfective ocular conditions)

Dosing

Adult: 150–200 mg daily by mouth in 2–4 divided doses, then increased to 300 mg daily; dose to be increased only in acute conditions
Pediatric: Child 12–17 years: 150–200 mg daily by mouth in 2–4 divided doses, then increased to 300 mg daily; dose to be increased only in acute conditions
Max dose: 300 mg daily

Pharmacokinetics

Half-life

7.5 h

Protein binding

99%

Metabolism

CYP2C9 oxidation, UGTB7 glucuronidation of parent and 4′-OH metabolite

Contraindications

History of hypersensitivity to aspirin or any other NSAID
Patients in whom attacks of asthma, angioedema, urticaria or rhinitis have been precipitated by aspirin or any other NSAID
pregnant women
peptic ulcer patients

Side effects

Common

Gastro-intestinal side-effects (more than ibuprofen)Transient elevations of hepatic transaminases (>1%)gastric discomfortnauseavomitingheadachedizzinessblurring of visiontinnitusdepressionrashesitchingfluid retentiongastric side effects

Serious

sterile corneal melts
perforations (especially in older patients with ocular surface disease)
gastric erosion (rare)
occult blood loss (rare)
precipitation of aspirin-induced asthma

Pregnancy & lactation

Pregnancy

Avoid during pregnancy (warning for topical preparations)

Lactation

Avoid during breast-feeding (warning for topical preparations)

Drug interactions

Aminoglycoside

Severe

Textbook

Increased risk of nephrotoxicity.

Avoid concurrent use.

Source: KDT 7e · p746

Aminoglycosides

Severe

Textbook

Increased aminoglycoside levels and potential toxicity.

Monitor aminoglycoside levels and renal function; adjust dosage as needed.

Source: KDT 7e

Anticoagulants

Severe

Textbook

Increased risk of gastrointestinal bleed.

Monitor for bleeding; consider alternative analgesics or gastroprotective agents.

Source: KDT 7e

Corticosteroids

Severe

Textbook

Increased risk of gastrointestinal bleed.

Monitor for bleeding; consider gastroprotective agents.

Source: KDT 7e

Dapoxetine

Severe

Textbook

Increased risk of gastrointestinal bleed.

Monitor for bleeding; consider gastroprotective agents or alternative analgesics.

Source: KDT 7e

Enalaprilat

Severe

Textbook

Reduced effectiveness of ACE inhibitors. Marked hyperkalemia, potentially leading to cardiac arrhythmia.

Use with caution, especially in the elderly and in patients with hypertension, diabetes mellitus, or ischemic heart disease.

Source: G&G 14e · p836

Escitalopram + Clonazepam

Severe

Textbook

Increased risk of gastrointestinal bleed.

Monitor for bleeding; consider gastroprotective agents or alternative analgesics.

Source: KDT 7e

Glucocorticoids

Severe

Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Quinolones

Severe

Textbook

Enhanced neurological adverse effects.

Use with caution, especially in patients with a history of epilepsy.

Source: G&G 14e · p1144

Acalabrutinib

Severe

Database

Drug interaction classified as: synergy