Abarelix
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Iloperidone
Atypical Antipsychotic · Antipsychotic
Atypical AntipsychoticAntipsychotic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
C
FDA category + note
Top interactionssee all 12 →
- AbarelixSevereDatabaseDDInter
- AbirateroneSevereDatabaseDDInter
- AdenosineSevereDatabaseDDInter
- AlfentanilSevereDatabaseDDInter
Mechanism
Iloperidone is a second-generation antipsychotic that acts as an inverse agonist at 5-HT2A receptors, blocking their constitutive activity. This action modulates the release of dopamine, norepinephrine, glutamate, GABA, and acetylcholine. It also blocks D2 receptors and may act as a 5-HT2C inverse agonist, contributing to the inhibition of cortical and limbic dopamine release.
Indications
Schizophrenia
Dosing
- Adult
- NMDA receptor is not fully saturated. There have been several trials of high doses of glycine to promote glutamatergic activity, but the results are far from convincing. Currently, glycine transport inhibitors are in development as possible psychotropic agents. Ampakines are drugs that potentiate currents mediated by AMPAtype glutamate receptors.…
Pharmacokinetics
Peak effect
2–4 h
Half-life
18 h (CYP2D6 EMs), 33 h (CYP2D6 PMs). P88 t1/2: 26 h (EM), 37 h (PM). P95 t1/2: 23 h (EM), 31 h (PM).
Bioavailability
Well absorbed
Metabolism
CYP2D6/3A4 produce active metabolites P88 and P95.
Contraindications
- Use in elderly dementia patients (increased mortality risk)
Side effects
Common
Low risk of metabolic adverse effectsorthostasis (requires slow titration)
Serious
- Neuroleptic malignant syndrome
- increased mortality in elderly dementia patients
Pregnancy & lactation
Pregnancy
C
Lactation
Not specified
Drug interactions
Abiraterone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Adenosine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfuzosin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alimemazine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Atypical Antipsychotic drugs
Ask House about Iloperidone
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung·Verified: 2026-05-13 · House clinical team