Amiodarone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
Nafcillin
Penicillin · Antibiotic
Also known as Nallpen
PenicillinAntibiotic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AmiodaroneSevereDatabaseDDInter
- AnisindioneSevereDatabaseDDInter
- AvapritinibSevereDatabaseDDInter
- AxitinibSevereDatabaseDDInter
Mechanism
Nafcillin, like other beta-lactam antibiotics, inhibits bacterial growth by interfering with the transpeptidation reaction during bacterial cell wall synthesis. It acts as a structural analog of the D-Ala-D-Ala substrate and covalently binds to the active site of penicillin-binding proteins (PBPs), thereby inhibiting peptidoglycan synthesis and leading to bacterial cell death.
Indications
Infections caused by staphylococci and streptococciAs an antistaphylococcal agent if Staphylococcus aureus is suspected (e.g., in severe pneumonia, meningitis)Skin and soft-tissue infectionsSerious infections due to MSSASerious infections sensitive to methicillin but resistant to penicillin
Dosing
- Adult
- doses between 3 and 12 mg/m2. A high-fat meal decreases peak. minimize toxicity varies, 3-5 mg/kg/day is the usual. starting dose. Lower initial doses (1 mg/kg/day) are used
Side effects
Common
neutropeniahepatitis (rare)impaired hemostasis (defective platelet aggregation)Gastrointestinal side effects (e.g., diarrhea)
Serious
- Hypersensitivity reactions (rash to anaphylaxis)
- Serum sickness
- Stevens-Johnson syndrome
- Nephropathy
- Hematologic reactions (neutropenia, prolonged use)
- Neurotoxicity (seizure, high doses, renal impairment)
Drug interactions
Anisindione
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Avapritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Axitinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bosutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Brigatinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Capmatinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Cobimetinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Daclatasvir
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Penicillin drugs
Ask House about Nafcillin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team